|
KMID : 0061119820100000024
|
|
Bulletin of the Clinical Research Institute
1982 Volume.10 No. 0 p.24 ~ p.24
|
|
|
Leukocyte Migration Inhibitory Response and the Influence of Serum Factor on Lymphocyte Blastogenesis in Minimal Change Nephrotic Syndrome
|
|
Kim, Ho-Youn
Bang, Byung-Kee/Chung, Hee-Young/Min, Byong-Sok
|
|
|
Abstract
|
|
|
In an attempt to evaluate cellular immune response in minimal change nephrotic syndrome, eighteen cases, confirmed by biopsy, were studied with Mantoux test, direct and indirect leukocyte migration inhibition test and PHA-P stimulated ^(3)H-thymidine incorporation of lymphocytes pretreatment with autologous and homologous serum.
Mantoux test and direct leukocyte migration inhibition test were negative in 12 of 15 cases (80%) and 14 of 15 cases (93.3%) in active stages of the disease. In follow-up study, 8 of 12 negative cases were converted to positive response in in-active stages. .
Leukocyte migration inhibitory response of PHA-P stimulated mononuclear cells in active stage of minimal change nephrotic syndrome was weaker than that in normal subjects.
PHA-P stimulated ^(3)H-thymidine incorporation of the lymphocyte in active stage was significantly decreased than that of normal subjects, and increased to normal levels after pretreatment with the normal serum.
PHA-P stimulated ^(3)H-thymidine incorporation of the normal lymphocyte after pretreatment with the serum in active stage of the disease was significantly lower than that after pretreatment with the normal serum.
From these results, it is concluded that a serum factor, probably secreted by the immunoregulatory cells in active stage of the disease, inhibits lymphocyte blastogenesis and delayed type hypersensitivity reaction both in vitro and vivo.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|